Ca-AKG has been proven to extend lifespan and health span in mammals, this is why DoNotAge is now stocking it. AKG is a key metabolite in the KREBS cycle (energy) and plays a role in metabolism, stem cell growth, collagen synthesis and epigenetic regulation. As with many other key health metrics, AKG levels decrease with age. It has been proven that your AKG levels at 80 are just 10% of what they were when you were 40! AKG cannot be increased from your diet. Studies have shown it can: Help with weight. Turn white fat to brown fat. Extend a healthy lifespan. Strengthen bones. Reduce inflammation from senescent cells. Have an effect on hair/fur colour.