Methylation Support Helps Methylation and Detoxification Pathways, Especially In Those With MTHFR SNP† Methylation Support delivers activated B vitamins in their most bioavailable forms to promote the body’s detoxification processes and balanced homocysteine levels.† Support the Body's Detoxification Pathways With Methylation Support®† If you have or suspect MTHFR SNPs, you should consider Methylation Support®. Methylation is a biochemical process that, among many other critical functions, plays a crucial role in the body’s detoxification pathways. Methylation depends on a number of vitamins and cofactors, including folate, vitamin B12, and vitamin B6.