Ginseng berries have been under-appreciated. Recent studies on Ginseng berries suggest they have 60% more ginsenosides than in the root and four not found in the root. Additionally, berries contain vitamins, minerals, and beneficial plant polyphenols. Research evaluating ginseng berry's efficacy is limited to preclinical studies. Still, it has promising potential as a mental health-promoting nutraceutical due to the higher levels of ginsenosides' anti-inflammatory and antioxidant actions. Rb3, Re, Rb2, Rd, and Rc are the ginsenosides most abundant in the American ginseng berry; assessing their composition via high-performance liquid chromatography (HPLC) suggests they're superior in promoting gut health. Furthermore, an anti-aging component of the ginseng berry, syringaresinol, has the potential for activating the longevity genes sirt1 and foxo, which offers the potential to be widely used as an anti-aging reagent for many age-related health issues and to increase overall vitality.