Pet Remedy's Natural De-Stress & Calming formula is a unique and clinically proven formula of Valerian absolute oil with small inclusions of Vetiver, Basil & Clary Sage essential oils. The low concentration of oils is very gentle in its effect and works with your pet’s own natural calming mechanisms by mimicking GABA (gamma amino butyric acid), which is a natural calming agent present in mammals, birds, and reptiles. This calming spray is water based and pH neutral, making it safe for use on skin and coat of pet. Starts to help instantly and the effects last for 2-6 hours depending on individual pet.