Jones Natural Chews Bully Stick Twister Large are made of 2 natural, USA-raised beef pizzles that are twisted together and then slow-roasted in their own casing-creating a more flavorful and longer-lasting chew. These are appropriate for any size dog and a wonderful low-fat chew that is fully digestible and a great source of protein without any artificial ingredients added. Dogs will enjoy this dense chew for a long time, making it a tasty option for powerful chewers. All Jones Natural Chews products are raised and handcrafted in the USA and responsibly sourced.