“Finding D-Mannose Natural Defense + has truly changed my life!” —Annie B, Nuzena customer D-Mannose Natural Defense + Is A Women's Shield Against UTI's Nuzena D-Mannose Natural Defense + formula provides natural support against UTI’s, supports healthy bladder function, and supports healthy liver function. Developed by healthcare professionals, this formula is made with scientifically backed ingredients that help protect against UTI’s.