Key Ingredients affron® Saffron In more than 5 published human clinical studies, affron® Saffron has been shown as effective at a low daily dose of 28 mg to calm occasional irritability and stress, promote mental balance, maintain a healthy mood and to support restful sleep. Made from Spanish saffron (Crocus sativus), affron's patented formulation is standardized to provide 3.5% Lepticrosalides®, a complex of bioactive compounds responsible for its beneficial and organoleptic properties. Affron's dual mechanisms of action include * reuptake inhibition of dopamine, norepinephrine and serotonin, increasing the concentration of these neurotransmitters in the synaptic cleft of neurons, thereby improving mood balance * antioxidant effect against the excessive oxidative stress produced during anxiety or stress processes in the central nervous system. Echinacea augustifolia Echinacea augustifolia supports in reducing occasional tension and promoting a relaxed, positive mood. While this herb is typically associated with immune system support, the root extract in our formula contains alkamides along with echinacosides. It has been found that alkamides bind significantly to and activate the body's cannabinoid (CB2) receptors in the endocannabinoid system. Alkamides are bioactive compounds that show structural similarity with anandamide, an endogenous ligand of cannabinoid receptors. Anandamide is a neurotransmitter that binds to cannabinoid receptors in the brain and body, stimulating a sense of happiness and mental balance. Anandamide is a little-known brain chemical that's been called the “bliss molecule” for the role it plays in producing feelings of happiness. Suggested Use Adults and adolescents age 12 and up, take 1 serving orally (4 sprays) in divided doses (2 sprays in the morning and 2 sprays in the evening). For best results, use consistently approximately every 12 hours to ensure the body has an effective amount at all times. Warnings Do not take if pregnant or nursing. If taking any medications, consult doctor before use. Discontinue use and consult doctor if any adverse reactions occur. Keep out of reach of children.